- Written by Pssusa GPCSEC
Gel Permeation Chromatography (GPC), Size Exclusion Chromatography (SEC), or Gel Filtration Chromatography (GFC) are names used interchangeably for a liquid chromatography technique to obtain the molecular weight distribution of a polymer.
You must select the right eluent and the right column material to complete the separation successfully. Any interaction with the column must be prevented (contrary to normal HPLC methods that rely on those interactions). Only the entropy effects should influence the separation.